Cirphles
�cole normale sup�rieure CNRS

Michel Morange

English

Biographie :

Michel Morange a reçu une formation en biochimie et biologie moléculaire à l’Université Paris 7. Il a préparé sous la direction d’Henri Buc et soutenu sa thèse sur les protéines allostériques à l’Institut Pasteur de Paris en 1978. Il s’est ensuite tourné vers la biologie du développement, et a rejoint le laboratoire de génétique cellulaire dirigé par François Jacob. De 1991 à 2009 il a co-dirigé avec Olivier Bensaude un groupe de recherche sur la régulation des gènes de choc thermique. Michel Morange est Professeur de Biologie à l’Université Paris 6 et à l’École normale supérieure.
Il a reçu en parallèle une formation en Histoire et en Philosophie des sciences (Doctorat de 3ème cycle obtenu en 1978 sous la Direction du Professeur Jacques Merleau-Ponty à l’Université Paris X). Il dirige le Centre Cavaillès d’Histoire et de Philosophie des sciences de l’Ens (CIRPHLES, USR 3308).
Son travail historique a porté sur les transformations de la biologie au XXème siècle, et en particulier l’essor de la biologie moléculaire. Il a aussi discuté des forces et des limites de l’approche génétique. Plus récemment, il s’est intéressé à l’émergence au sein des sciences du vivant de nouvelles disciplines, biologie des systèmes, biologie synthétique, épigénétique. Il a travaillé sur la critique du réductionnisme, le rôle croissant de l’interdisciplinarité, et la réémergence de la question de la vie.

Ouvrages :

Michel Morange (1986) Une lecture du vivant : Histoire et épistémologie de la biologie moléculaire (Louvain la Neuve : Ciaco éd.)

Michel Morange éd. (1991) L’Institut Pasteur : Contributions à son histoire (Paris : La Découverte)

Michel Morange (1994) Histoire de la Biologie Moléculaire (Paris : La Découverte)

Michel Morange (1998) La part des gènes (Paris : Odile Jacob)

Nadine Peyriéras et Michel Morange éds. (2002) Les travaux scientifiques de François Jacob (Paris : Odile Jacob)

Michel Morange (2003) La vie expliquée ? 50 ans après la double hélice (Paris : Odile Jacob)

Michel Morange (2005) Les secrets du vivant : Contre la pensée unique en biologie (Paris : La Découverte)

Michel Morange (2008) A quoi sert l’histoire des sciences ? (Paris : Quae ed.)

Michel Morange (2011) La vie, l’évolution et l’histoire (Paris : Odile Jacob)

Liste des articles récents (2007-2012) :

Michel Morange (2007) The progressive construction of a mechanism for prion diseases. J. Biosci. 32 223-227

Michel Morange (2007) The field of cancer research : an indicator of present transformations in biology. Oncogene 26 7607-7610

Michel Morange (2007) z-DNA : When nature is not opportunistic. J. Biosci. 32 657-661

Michel Morange (2007) Fifty years ago : The beginnings of exobiology. J. Biosci. 32 1083-
1087

Michel Morange (2007) French tradition and the rise of Evo-devo. Theor. Biol. 126 149-153

Michel Morange (2007) The complex history of chemiosmotic theory. J. Biosci. 32 1245-
1250

Michel Morange (2007) Physics, History and Biology. Interdisciplinary science reviews 32
107-112

Michel Morange (2008) Boris Ephrussi’s continuing efforts to create a « genetics of
differentiation »
. J. Biosci. 33 21-25

Michel Morange (2008) Fifty years of the Central Dogma. J. Biosci. 33 171-175


Michel Morange (2008) Regulation of gene expression by non-coding RNAs : the early steps. J. Biosci. 33 327-331

Michel Morange (2008) Cyril Norman Hinshelwwod (1897-1967) – a chemical dynamic
vision of the organic world
. J. Biosci. 33 669-672

Michel Morange (2008) The death of molecular biology ? Hist. Phil. Life Sci. 30 31-42

Michel Morange (2009) A third pillar for molecular biology : molecular embryology. J.
Biosci.
34 17-20

Michel Morange (2009) Conrad Waddington and The nature of life. J. Biosci. 34 195-198

Michel Morange (2009) When functional biologists propose mechanisms of evolution. J.
Biosci.
34 373-376

Michel Morange (2009) A new revolution ? The place of systems biology and synthetic
biology in the history of biology
. EMBO reports 10 S50-53

Michel Morange (2009) How phenotypic plasticity made its way into molecular biology. J.
Biosci.
34 495-501

Michel Morange (2009) The notion of the episome. J. Biosci. 34 845-848

Stephane Tirard, Michel Morange and Antonio Lazcano (2010) The Definition of Life : A
brief History of an Elusive Scientific Endeavor. Astrobiology 10 : 1003-1009

Jean Gayon , Christophe Malaterre, Michel Morange, Florence Raulin-Cerceau and Stéphane Tirard (2010) Defining life : Conference proceedings. Orig. Life Evol. Biosph. 40 119-120

Michel Morange (2010) The resurrection of Life. Orig. Life Evol. Biosphere 40 179-182

Michel Morange (2010) Felix Haurowitz (1896-1987) – A difficult journey in the political
and scientific upheavals of the 20th century
. J. Biosci. 35 17-20

Michel Morange (2010) Apoptosis and programmed cell death : when biological categories
are blurred
. J. Biosci. 35 177-181

Michel Morange (2010) The scientific legacy of Jacques Monod. Res. Microbiol. 161 77-81

Michel Morange (2010) The French Neo-Lamarckians. J. Biosci. 35 515-517

Michel Morange (2011) Development and aging. Biological Theory DOI 10.1007/s13752-
011-0010-6

Ute Deichmann, Michel Morange and Eric Davidson (2011) Introductory comment on six
papers from a symposium on experimental and historical aspects of evolutionary bioscience. Dev. Biol. 357 2

Michel Morange (2011) Evolutionary developmental biology : Its roots and characteristics.
Dev. Biol. 357 13-16

Michel Morange (2011) The genetic distance between humans and chimpanzees : What did Mary-Claire King and Allan Wilson really say in 1975 ? J. Biosci. 36 23-26

Michel Morange (2011) The attempt of Nikolai Koltzoff (Koltsov) to link genetics, embryology and physical chemistry. J. Biosci. 36 211-214

Michel Morange (2011) Recent opportunities for an increasing role for physical explanations in biology. Stud. Hist. Phil. Biol. Biomed. Sci. 42 139-144

Michel Morange (2011) What will result from the interaction between functional and
evolutionary biology ? Stud. Hist. Phil. Biol. Biomed. Sci. 42 69-74

Michel Morange (2011) Some considerations on the nature of LUCA, and the nature of life.
Res. Microb. 162 5-9

Michel Morange (2011) Construction of the ribbon model of proteins : The contribution of
Jane Richardson
. J. Biosci. 36 571-574

Michel Morange (2011) From Mechnikov to proteotoxicity : ageing as the result of an
intoxication
. J. Biosci. 36 769-772

Michel Morange (2012) What might be a new view of evolution ? Stud. Hist. Phil. Biol.
Biomed. Sci.
43 578-581

Michel Morange (2012) A new life for allostery. J. Biosci. 37 13-17

Michel Morange (2012) What is really new in the current evolutionary theory of cancer ? J.
Biosci.
37 609-612

Michel Morange (2012) The recent evolution of the question « What is Life ? ». Hist. Phil.
Life Sci.
34 425-438

Michel Morange (2012) Transfers from plant biology : From cross protection to RNA
interference and DNA vaccination
. J. Biosci. 37 949-952

Chapitres d’ouvrages (2007-2012) :

Michel Morange (2010) How evolutionary biology presently pervades cell and molecular
biology in Darwinism, philosophy and experimental biology (Ute Deichmann and Anthony S. Travis eds) (Heidelberg : Springer) 59-66

Michel Morange (2011) Problems raised by a definition of life in Origins and Evolution of
Life
(Muriel Gargaud, Purificacion Lopez-Garcia and Herve Martin eds) (Cambridge :
Cambridge University Press) 3-13

Michel Morange (2011) Explanatory relationships between chemical and biological sciences in Handbook of the philosophy of science vol. 6 : Philosophy of Chemistry (Andrea L. Woody, Robin Findlay Hendry and Paul Needham eds) (Amsterdam : Elsevier) 509-518

Principaux articles publiés avant 2007 :

Michel Morange (1983) Schrödinger et la biologie moléculaire. Fundamenta Scientiae 4 219-234

Michel Morange (1993) The discovery of cellular oncogenes. Hist. Phil. Life Sci. 15 45-58

Michel Morange (1996) Construction of the developmental gene concept. The crucial years :
1960-1980. Biol. Zent. bl. 115 13é)138

Michel Morange (1997) The transformation of molecular biology on contact with higher organisms, 1960-1980 : from a molecular description to a molecular explanation. Hist. Phil. Life Sci. 19 369-393

Michel Morange (1997) From the regulatory vision of cancer to the oncogene paradigm,
1975-1985. J. Hist. Biol. 30 1-29

Michel Morange (2000) Gene Funnction. CR Acad. Sci. Paris III 323 1147-1153

Michel Morange (2000) François Jacob’s lab in the seventies : the T-complex and the mouse developmental genetic program. Hist. Phil. Life Sci. 22 397-411

Michel Morange (2000) Georges Canguilhem et la biologie du XXe siècle. Rev. Hist. Sci. 53
83-105

Michel Morange (2001) A successful form of reductionism : a historical perspective. The Biochemist 23 37-39

Michel Morange (2001) On the relation between history and philosophy of the life sciences
and biology. Hist. Phil. Ltfe Sci. 23 65-74

Michel Morange (2002) The relations between genetics and epigenetics : a historical point of view. Ann. New York Acad. Sci. 981 50-60

Michel Morange (2002) L’Institut de Biologie Physico-chimique : de sa fondation à l’entrée
dans l’ère moléculaire. La revue pour l’histoire du CNRS 7 32-40

Michel Morange (2003) History of Cancer Research. Encyclopedia of Life Sciences, Nature
publishing Group, A3088

Michel Morange (2004) Les publications de François Jacob. Genesis 20 81-89

Michel Morange (2004) Joshua Lederberg. Encyclopedia of Life Sciences, Nature publishing group, A2855

Michel Morange (2004) The death of Francis Crick : the end of a golden age in biology. J. Biosci. 29 378-380

Michel Morange (2005) The operon model and its legacy. J. Biosci. 30 313-316

Michel Morange (2005) The discovery of chaperone function. J. Biosci. 30 461-464


Michel Morange (2005) André Lwoff : from protozoology to molecular definition of viruses.
J. Biosci. 30 591-594

Michel Morange (2005) Henri Atlan’s early writings. Cell. Mol. Biol. 14 625-628

Michel Morange (2006) Ciliates as models... of what ? J. Biosci. 31 27-30

Michel Morange (2006) Emile Duclaux 1840-1904. J. Biosci. 31 215-218

Michel Morange (2006) The transfer of behaviours by macromolecules. J. Biosci. 31 323-327

Michel Morange (2006) Twenty-five years ago : the production of mouse embryonic stem
cells
. J. Biosci. 31 537-541

Michel Morange (2006) Post-genomics, between reduction and emergence. Synthese 151 355-360

Michel Morange (2006) The protein side of the Central Dogma : permanence and change. Hist. Phil. Life Sci. 28 513-524

Chapitres d’ouvrages publiés avant 2007 :

Michel Morange (1988) Condorcet et les naturalistes de son temps in Sciences à l’époque de la Révolution française : recherches historiques (Paris : Albert Blanchard), 445-464

Michel Morange (1996) Article Monod Jacques in le Dictionnaire des Intellectuels français, J. Julliard et M. Winock éds. (Paris : Le Seuil), 800-801

Michel Morange (1996) Article eugénisme in le Dictionnaire d’Ethique et de philosophie
morale
, M. Canto-Sperber éd. (Paris : Presses Universitaires de France), 540-543

Michel Morange (1997) EMBO and EMBL in History of European Scientific and
Technological Cooperation
, J. Krige ed., Publications of the European Communities.

Michel Morange (2000) The developmental gene concepts : history and limits in The concept of the gene in development and evolution : historical and epistemological perspectives, P. Beurton, R. Falk and H.-J. Rheinberger eds. (Cambridge : Cambridge University Press), 193-215

Michel Morange (2006) Articles Jacob, Monod and Life sciences in The Columbia history of
twentieth-century French thought
, L. D. Kritzman ed. (New York : Columbia University
Press) 

Biography :

Michel Morange was trained in biochemistry and molecular biology at the Pasteur Institute in Paris, where he obtained his PhD in 1978. He then turned to cell biology, and entered into François Jacob’s lab in the same Institute. He created in 1991, at the Ecole normale supérieure in Paris, a group whose project was to characterize the regulation of heat shock gene expression. Michel Morange is Professor in Biology at the University Paris 6 and at the Ecole normale supérieure.
Michel Morange received also in parallel a formation in history and philosophy of sciences (PhD in 1978). He is the Director of the Centre Cavaillès for History and philosophy of sciences at the Ecole normale supérieure (CIRPHLES, USR 3308). Most of his work is devoted to the history of the transformations of biology during the 20th century – in particular the rise of molecular biology. He also discussed the strengths and limits of the genetic vision.
More recently, he turned his attention to the extant transformations of biology, with the rise of new disciplines such as systems biology and synthetic biology, the increasing place of epigenetics, the criticism of reductionism, the growing role of interdisciplinarity, and the reemergence of the question of life.

Books published in English :

Michel Morange (1998) A history of molecular biology (Cambridge : Harvard University press)

Michel Morange (2001) The misunderstood gene (Cambridge : Harvard University Press

Michel Morange (2008) Life explained (New Haven : Yale University Press)

 

List of recently published articles (2007-2012) :

Michel Morange (2007) The progressive construction of a mechanism for prion diseases. J. Biosci. 32 223-227

Michel Morange (2007) The field of cancer research : an indicator of present transformations in biology. Oncogene 26 7607-7610

Michel Morange (2007) z-DNA : When nature is not opportunistic. J. Biosci. 32 657-661

Michel Morange (2007) Fifty years ago : The beginnings of exobiology. J. Biosci. 32 1083-1087

Michel Morange (2007) French tradition and the rise of Evo-devo. Theor. Biol. 126 149-153

Michel Morange (2007) The complex history of chemiosmotic theory. J. Biosci. 32 1245-
1250

Michel Morange (2007) Physics, History and Biology. Interdisciplinary science reviews 32
107-112

Michel Morange (2008) Boris Ephrussi’s continuing efforts to create a « genetics of differentiation ». J. Biosci. 33 21-25

Michel Morange (2008) Fifty years of the Central Dogma. J. Biosci. 33 171-175

Michel Morange (2008) Regulation of gene expression by non-coding RNAs : the early steps. J. Biosci. 33 327-331

Michel Morange (2008) Cyril Norman Hinshelwwod (1897-1967) – a chemical dynamic
vision of the organic world
. J. Biosci. 33 669-672

Michel Morange (2008) The death of molecular biology ? Hist. Phil. Life Sci. 30 31-42

Michel Morange (2009) A third pillar for molecular biology : molecular embryology. J.
Biosci.
34 17-20

Michel Morange (2009) Conrad Waddington and The nature of life. J. Biosci. 34 195-198

Michel Morange (2009) When functional biologists propose mechanisms of evolution. J.
Biosci.
34 373-376

Michel Morange (2009) A new revolution ? The place of systems biology and synthetic
biology in the history of biology
. EMBO reports 10 S50-53

Michel Morange (2009) How phenotypic plasticity made its way into molecular biology. J.
Biosci
. 34 495-501

Michel Morange (2009) The notion of the episome. J. Biosci. 34 845-848

Stephane Tirard, Michel Morange and Antonio Lazcano (2010) The Definition of Life : A brief History of an Elusive Scientific Endeavor. Astrobiology 10 : 1003-1009

Jean Gayon , Christophe Malaterre, Michel Morange, Florence Raulin-Cerceau and Stéphane Tirard (2010) Defining life : Conference proceedings. Orig. Life Evol. Biosph. 40 119-120

Michel Morange (2010) The resurrection of Life. Orig. Life Evol. Biosphere 40 179-182

Michel Morange (2010) Felix Haurowitz (1896-1987) – A difficult journey in the political
and scientific upheavals of the 20th century
. J. Biosci. 35 17-20

Michel Morange (2010) Apoptosis and programmed cell death : when biological categories
are blurred
. J. Biosci. 35 177-181

Michel Morange (2010) The scientific legacy of Jacques Monod. Res. Microbiol. 161 77-81

Michel Morange (2010) The French Neo-Lamarckians. J. Biosci. 35 515-517

Michel Morange (2011) Development and aging. Biological Theory DOI 10.1007/s13752-011-0010-6

Ute Deichmann, Michel Morange and Eric Davidson (2011) Introductory comment on six papers from a symposium on experimental and historical aspects of evolutionary bioscience. Dev. Biol. 357 2

Michel Morange (2011) Evolutionary developmental biology : Its roots and characteristics. Dev. Biol. 357 13-16

Michel Morange (2011) The genetic distance between humans and chimpanzees : What did Mary-Claire King and Allan Wilson really say in 1975 ? J. Biosci. 36 23-26

Michel Morange (2011) The attempt of Nikolai Koltzoff (Koltsov) to link genetics, embryology and physical chemistry. J. Biosci. 36 211-214

Michel Morange (2011) Recent opportunities for an increasing role for physical explanations in biology. Stud. Hist. Phil. Biol. Biomed. Sci. 42 139-144

Michel Morange (2011) What will result from the interaction between functional and evolutionary biology ? Stud. Hist. Phil. Biol. Biomed. Sci. 42 69-74

Michel Morange (2011) Some considerations on the nature of LUCA, and the nature of life.
Res. Microb. 162 5-9

Michel Morange (2011) Construction of the ribbon model of proteins : The contribution of
Jane Richardson
. J. Biosci. 36 571-574

Michel Morange (2011) From Mechnikov to proteotoxicity : ageing as the result of an intoxication. J. Biosci. 36 769-772

Michel Morange (2012) What might be a new view of evolution ? Stud. Hist. Phil. Biol.
Biomed. Sci.
43 578-581

Michel Morange (2012) A new life for allostery. J. Biosci. 37 13-17

Michel Morange (2012) What is really new in the current evolutionary theory of cancer ? J. Biosci. 37 609-612

Michel Morange (2012) The recent evolution of the question « What is Life ? ». Hist. Phil.
Life Sci.
34 425-438

Michel Morange (2012) Transfers from plant biology : From cross protection to RNA interference and DNA vaccination. J. Biosci. 37 949-952
 

Chapters of books (2007-2012) :

Michel Morange (2010) How evolutionary biology presently pervades cell and molecular biology in Darwinism, philosophy and experimental biology (Ute Deichmann and Anthony S. Travis eds) (Heidelberg : Springer) 59-66

Michel Morange (2011) Problems raised by a definition of life in Origins and Evolution of Life (Muriel Gargaud, Purificacion Lopez-Garcia and Herve Martin eds) (Cambridge : Cambridge University Press) 3-13

Michel Morange (2011) Explanatory relationships between chemical and biological sciences in Handbook of the philosophy of science vol. 6 : Philosophy of Chemistry (Andrea L. Woody, Robin Findlay Hendry and Paul Needham eds) (Amsterdam : Elsevier) 509-518

Main articles published before 2007 :

Michel Morange (1983) Schrödinger et la biologie moléculaire. Fundamenta Scientiae 4 219-234

Michel Morange (1993) The discovery of cellular oncogenes. Hist. Phil. Life Sci. 15 45-58

Michel Morange (1996) Construction of the developmental gene concept. The crucial years : 8 1960-1980. Biol. Zent. bl. 115 13é)138

Michel Morange (1997) The transformation of molecular biology on contact with higher organisms, 1960-1980 : from a molecular description to a molecular explanation. Hist. Phil. Life Sci. 19 369-393

Michel Morange (1997) From the regulatory vision of cancer to the oncogene paradigm, 1975-1985. J. Hist. Biol. 30 1-29

Michel Morange (2000) Gene Funnction. CR Acad. Sci. Paris III 323 1147-1153

Michel Morange (2000) François Jacob’s lab in the seventies : the T-complex and the mouse developmental genetic program. Hist. Phil. Life Sci. 22 397-411

Michel Morange (2000) Georges Canguilhem et la biologie du XXe siècle. Rev. Hist. Sci. 53 83-105

Michel Morange (2001) A successful form of reductionism : a historical perspective. The Biochemist 23 37-39

Michel Morange (2001) On the relation between history and philosophy of the life sciences and biology. Hist. Phil. Life Sci. 23 65-74

Michel Morange (2002) The relations between genetics and epigenetics : a historical point of view. Ann. New York Acad. Sci. 981 50-60

Michel Morange (2002) L’Institut de Biologie Physico-chimique : de sa fondation à l’entrée dans l’ère moléculaire. La revue pour l’histoire du CNRS 7 32-40

Michel Morange (2003) History of Cancer Research. Encyclopedia of Life Sciences, Nature publishing Group, A3088

Michel Morange (2004) Les publications de François Jacob. Genesis 20 81-89

Michel Morange (2004) Joshua Lederberg. Encyclopedia of Life Sciences, Nature publishing group, A2855

Michel Morange (2004) The death of Francis Crick : the end of a golden age in biology. J. Biosci. 29 378-380

Michel Morange (2005) The operon model and its legacy. J. Biosci. 30 313-316

Michel Morange (2005) The discovery of chaperone function. J. Biosci. 30 461-464

Michel Morange (2005) André Lwoff : from protozoology to molecular definition of viruses. J. Biosci. 30 591-594

Michel Morange (2005) Henri Atlan’s early writings. Cell. Mol. Biol. 14 625-628

Michel Morange (2006) Ciliates as models... of what ? J. Biosci. 31 27-30

Michel Morange (2006) Emile Duclaux 1840-1904. J. Biosci. 31 215-218

Michel Morange (2006) The transfer of behaviours by macromolecules. J. Biosci. 31 323-327

Michel Morange (2006) Twenty-five years ago : the production of mouse embryonic stem cells. J. Biosci. 31 537-541

Michel Morange (2006) Post-genomics, between reduction and emergence. Synthese 151 355-360

Michel Morange (2006) The protein side of the Central Dogma : permanence and change. Hist. Phil. Life Sci. 28 513-524

Chapters of books published before 2007 :

Michel Morange (1988) Condorcet et les naturalistes de son temps in Sciences à l’époque de la Révolution française : recherches historiques (Paris : Albert Blanchard), 445-464

Michel Morange (1996) Article Monod Jacques in le Dictionnaire des Intellectuels français, J. Julliard et M. Winock éds. (Paris : Le Seuil), 800-801

Michel Morange (1996) Article eugénisme in le Dictionnaire d’Ethique et de philosophie morale, M. Canto-Sperber éd. (Paris : Presses Universitaires de France), 540-543

Michel Morange (1997) EMBO and EMBL in History of European Scientific and Technological Cooperation, J. Krige ed., Publications of the European Communities.

Michel Morange (2000) The developmental gene concepts : history and limits in The concept of the gene in development and evolution : historical and Epistemological perspectives, P. Beurton, R. Falk and H.-J. Rheinberger eds. (Cambridge : Cambridge University Press), 193-215

Michel Morange (2006) Articles Jacob, Monod and Life sciences in The Columbia history of twentieth-century French thought, L. D. Kritzman ed. (New York : Columbia University Press)

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